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Minoxidil has neuroprotective effects against paclitaxel in primary cultured DRG neurons and alleviated paclitaxel-induced CIPN by inhibiting neuroinflammation and remodeling the dysregulation of intracellular calcium homeostasis in DRG neurons ( Inhibitor of OCT2 Transporter Activity The screening of a large-scale bioactive compound library (8,086 compounds) identified the FDA-approved TKI dasatinib as a potent inhibitor of the OCT2 transporter, which is involved in oxaliplatin uptake to the DRG (Sprowl et al., 2016)

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doi: 10.1016/j.ajog.2021.12.035

Identification of immune infiltration and the potential biomarkers in diabetic peripheral neuropathy through bioinformatics and machine learning methods

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Treatment with the combination according to the invention invariably yielded statistically significantly superior results as compared to the group treated with sildenafil alone in the tests reported in Tables 1- 10